INTERVENTION: Daily oral administration of or mg of Org, or mg desogestrel (reference group), for 21 days .
Org, compared with rat microsomal incubations. Both in vitro and in vivo, the majority of the metabolites were 3 - dihydro derivatives. In monkeys.
Pharmacokinetic differences between Caucasian and Japanese subjects after single and multiple doses of a potential combined oral contraceptive (Org.
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